ADENOSINE-DEAMINASE ACTIVITY IN THYMUS AND OTHER HUMAN TISSUES
Authors:
- A AdamsAAA Adams
- R A HarknessRHR A Harkness
- 1 January 1976
- journal article
- research article
- Vol. 26 (3) , 647-649
Abstract
Adenosine deaminase [EC 3.5.4.4] activity (ADA) was estimated in human tissues. Levels in the thymus during childhood were very much higher than in any of the other 6 tissues studied. Intermediate activities were obtained from spleen and lymph nodes and skin. Cerebral cortex, liver and kidney had relatively low levels. ADA activity in lymphocytes from peripheral blood was significantly increased after antigenic stimulation by TAB [typhoid paratyphoid AB vaccine] immunization. The available evidence appears to be consistent with T[thymus-derived]-lymphocyte growth and development in the thymus being dependent on ADA. [The pathogenesis of combined immunodeficiency in ADA deficiency is discussed.].Keywords
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