Effects of Prostaglandin E1in Canine Subcutaneous Adipose Tissue in Situ1
Authors:
- 10 December 1970
- journal article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 80 (4) , 450-458
Abstract
The effect of PGE1on the uptake of glucose and the release of FFA and glycerol before and after sympathetic nerve stimulation (4 cps) was investigated in perfused canine subcutaneous adipose tissuein situ. Glucose uptake was significantly increased by PGE1at all concentrations used (5 times 10‐10to 7 times 10‐7M in blood). The effect of PGE1on the release of FFA and glycerol in unstimulated adipose tissue was inconsistent. Increases as well as decreases were observed. Lipolysis, as measured by glycerol release, induced by nerve stimulation was inhibited dose‐dependently. A 50 per cent inhibition was produced by approximately 1.2 times 10‐7M PGE1. Stimulated FFA release was also inhibited but there was no clear dose‐response relationship. It is concluded that PGE1has similar effects in canine subcutaneous adipose tissue with an intact blood supply as are known to be producedin vitro.Keywords
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