A phase II study of a THP‐COP regimen for the treatment of elderly patients aged 70 years or older with diffuse large B‐cell lymphoma

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Abstract
Pirarubicin (tetrahydropyranyl adriamycin: THP) is an anthracycline drug that reportedly has fewer cardiotoxic effects than doxorubicin. A phase II study was conducted in order to determine the efficacy of a treatment regimen incorporating THP, namely THP‐COP in the treatment of elderly patients aged 70 years or older with diffuse large B‐cell lymphoma (DLBCL). The treatment regimens for Group A (aged 70–79 years,n = 45) and Group B (aged 80 years or older,n = 16) consisted of cyclophosphamide, THP, vincristine, and prednisolone, repeated six times, every 3 weeks. The complete remission rate was 72.1%. The 5‐year survival rate was 38.1%. For elderly patients with favourable prognostic factors, the 5‐year survival rate was significantly better at 77.9% compared with 15.6% for patients with poor prognostic factors (p < 0.01). Death associated with the treatment regimen was not observed. We conclude that the THP‐COP treatment regimen has fewer side effects and is very effective in the treatment of DLBCL in elderly patients, especially those with favourable prognostic factors. The present findings indicate the necessity of future studies investigating a combination therapy comprised of rituximab and THP‐COP for the treatment of elderly patients with CD20‐positive DLBCL. Copyright © 2007 John Wiley & Sons, Ltd.

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