RNA-seq analysis of synovial fibroblasts brings new insights into rheumatoid arthritis
Open Access
- 1 January 2012
- journal article
- Published by Springer Nature in Cell & Bioscience
- Vol. 2 (1) , 43
Abstract
Rheumatoid arthritis (RA) is a chronic autoimmune-disease of unknown origin that primarily affects the joints and ultimately leads to their destruction. Growing evidence suggests that synvovial fibroblasts play important roles in the initiation and the perpetuation of RA but underlying molecular mechanisms are not understood fully. In the present study, Illumina RNA sequencing was used to profile two human normal control and two rheumatoid arthritis synvovial fibroblasts (RASFs) transcriptomes to gain insights into the roles of synvovial fibroblasts in RA.Keywords
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