Sequential Interactions of the TCR with Two Distinct Cytoplasmic Tyrosine Kinases
- 25 February 1994
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 263 (5150) , 1136-1139
Abstract
The T cell antigen receptor (TCR) initiates signals by interacting with cytoplasmic protein tyrosine kinases (PTKs) through a 17-residue sequence motif [called the antigen recognition activation motif (ARAM)] that is contained in the TCRζ and CD3 chains. TCR stimulation induces the tyrosine phosphorylation of several cellular substrates, including the ARAMs. Lck kinase activity is required for phosphorylation of two conserved tyrosine residues in an ARAM. This phosphorylation leads to the recruitment of a second cytoplasmic PTK, ZAP-70, through both of the ZAP-70 Src homology 2 domains and its phosphorylation. Thus, TCR signal transduction is initiated by the sequential interaction of two PTKs with TCR ARAMs.Keywords
This publication has 41 references indexed in Scilit:
- ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chainCell, 1992
- Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptorCell, 1992
- The T Cell Receptor as a Multicomponent Signalling Machine: CD4/CD8 Coreceptors and CD45 in T Cell ActivationAnnual Review of Immunology, 1992
- Sequence requirements for induction of cytolysis by the T cell antigenFc receptor ζ chainCell, 1992
- The T cell receptor/CD3 complex is composed of at least two autonomous transduction modulesCell, 1992
- MOLECULAR AND GENETIC INSIGHTS INTO T CELL ANTIGEN RECEPTOR STRUCTURE AND FUNCTIONAnnual Review of Genetics, 1991
- Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptidesCell, 1991
- The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathwaysCell, 1991
- The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lckCell, 1988
- A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRACell, 1985