EXACERBATION OF PSORIASIS INDUCED BY INDOMETHACIN
Authors:
- 1 August 1981
- journal article
- case report
- Published by Wiley in The Journal of Dermatology
- Vol. 8 (4) , 323-327
Abstract
In an attempt to clarify the role of prostaglandins in the pathogenesis of psoriasis, indomethacin, a potent inhibitor of prostaglandin synthesis, was administered orally to 6 psoriatic patients and topically to 5 patients. In all cases remarkable exacerbation of pre‐existing lesions was observed within 1 to 4 weeks. The possible mechanism of the clinical exacerbation was discussed with particular reference to arachidonic acid‐prostaglandin system.Keywords
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