Low Concentrations of Taxol Cause Mitotic Delay Followed by Premature Dissociation of p55CDC from Mad2 and BubR1 and Abrogation of the Spindle checkpoint, Leading to Aneuploidy

Authors:
  • CYChia-Ping Huang Yang
    Chia-Ping Huang Yang
  • TMTomohiro Matsumoto
    Tomohiro Matsumoto
  • SHSusan Band Horwitz
    Susan Band Horwitz
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Abstract
Taxol is widely used for the treatment of human cancer. Its mechanism ofaction in cells is dependent on drug concentration. At low concentrations ofTaxol (5-10 nM), cells exhibit aberrant mitosis, ...