INFLUENCE OF DIETARY HEXACHLOROCYCLOHEXANE ISOMERS ON LIPID-METABOLISM IN ALBINO-RATS

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  • 1 February 1989
    • journal article
    • research article
    • Vol. 26  (1) , 34-38
    • PMID:2476378
Abstract
Dietary intake of .beta.- and .gamma.-hexachlorocyclohexane (.beta.- and .gamma.-HCH) by albino rats for two weeks (at 800 ppm level) resulted in impairment of lipid metabolism, viz. hyperlipemia and fatty metamorphosis of liver. Liver fat content was increased by both .beta.- and .gamma.-HCH. Significant increases were observed in triglyceride and phospholipid fractions of blood in these experimental animals. The incorporation of [14C]acetate and palmitate into liver and blood lipids was higher in HCH pretreated animals, suggesting a higher rate of fat synthesis in liver and of secretion as well.

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