Supramolecular Hunter Stationed on Red Blood Cells for Detoxification Based on Specific Molecular Recognition

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Abstract
Efficient removal of deadly toxicants by blood purification remains predominant in the poisoning treatment. Current strategies mainly rely on absorptive scavengers that normally have no selectivity to the adsorbates, which could result poor clinical outcomes to certain toxic species due to the passivity and inaccuracy of the detoxification procedure. Herein, a positive, accurate and customized detoxification strategy was proposed. Based on the sophisticated molecule-design and thoughtful structure-analysis of the aimed toxicant paraquat, a supramolecular-hunter stationed on red blood cells (RBC) is developed to continuously track paraquat in the blood. In this construct, a “Janus”-dendrimer-amphiphile (JDA) molecule was synthesized with the aim of facilely anchoring onto RBC membrane and meanwhile bridging to load the antidote WP6 that could precisely recognize paraquat. In vitro and in vivo results demonstrate an effective toxicant-hunting and harm-neutralizing capability of the system through a “Guest-Exchange” reaction. This strategy provides a different insight in designing scavengers that can actively, precisely and continuously hunt toxicant through a supramolecular approach.
Funding Information
  • Fudan University (FU-SIMM20182006)
  • Science and Technology Commission of Shanghai Municipality (2018SHZDZX01)
  • National Natural Science Foundation of China (21602030, 81872808)
  • Shanghai Institute of Materia Medica, Chinese Academy of Sciences (FU-SIMM20182006)
  • Shanghai Municipal Health and Family Planning Commission (20184Y0149)
  • Program of Shanghai Academic Research Leader (18XD1400500)

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