Control and sensation of breathing during cycling exercise in hypoxia under naloxone: a randomised controlled crossover trial

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Abstract
Opioid receptors are possibly involved in the perception of exertion and the ventilatory response to exercise. We compared incremental cycling exercise in conditions of normoxia and hypoxia (11% O2) after injection of the opioid receptor antagonist naloxone (30 mg i.v.) or placebo. Naloxone was expected to increase sensation of breathing and cycling and to curtail exercise performance more in hypoxia.

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