Comparative 1-Substituted Imidazole Inhibition of Cytochrome P450 Isozyme-Selective Activities in Human and Mouse Hepatic Microsomes
- 1 January 2007
- journal article
- research article
- Published by Taylor & Francis in Drug Metabolism Reviews
- Vol. 39 (2-3) , 309-322
Abstract
Inhibition of cytochrome P450(CYP)-selective reactions in a single human and a single mouse hepatic microsome preparation by fourteen 1-substituted imidazoles provides a simultaneous ranking of reaction susceptibility to a specific imidazole and the relative inhibitory potency of the imidazoles for a given reaction. CYP3A4/5 activity was inhibited (IC50 50 values for CYP3A4/5 50 value 50 50 values than in human microsomes.Keywords
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