DNA sequence determinants of CAP-induced bending and protein binding affinity
Authors:
- Marc R. GartenbergMGMarc R. Gartenberg
- Donald M. CrothersDCDonald M. Crothers
- 1 June 1988
- journal article
- Published by Springer Nature in Nature
- Vol. 333 (6176) , 824-829
Abstract
The sites of DNA bending induced by binding catabolite activator protein are identified and shown to coincide with positions where DNA grooves face the protein. The bendability of DNA with different sequences at these bend centres parallels the bending preference of the sequences in nucleosomal DNA. Anisotropic DNA bendability significantly affects the structure and strength of regulatory protein-DNA complexes.Keywords
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