Total Synthesis of Strigolactones via Palladium-Catalyzed Cascade Carbonylative Carbocyclization of Enallenes

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Abstract
Here we report an efficient route for synthesizing strigolactones (SLs) and their derivatives. Our method relies on a palladium-catalyzed oxidative carbonylation/carbocyclization/carbonylation/alkoxylation cascade reaction, which involves the formation of three new C-C bonds and a new C-O bond while cleaving one C(sp3)-H bond in a single step. With our versatile synthetic strategy, both naturally occurring and artificial SLs were prepared.
Funding Information
  • Xi?an Jiaotong University
  • Vetenskapsr?det (2018-00830, 2019-04042, 2022-03682)
  • Ministry of Science and Technology of the People's Republic of China
  • Knut och Alice Wallenbergs Stiftelse (KAW 2016.0072)
  • Olle Engkvists Stiftelse
  • National Natural Science Foundation of China (22001205)
  • China Western Overseas Postdoc Program (279866)

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