Rituximab in treatment of anti-GBM antibody glomerulonephritis

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Abstract
Rationale: Anti-glomerular basement membrane (GBM) disease is a T cell-mediated disease that has a poor prognosis with conventional therapy. We tested rituximab as a primary therapy to reduce anti-GBM antibody produced by B cells. Patient concerns: A 53-year old woman with complaints of a fever, headache and abdominal discomfort showed renal failure with elevated anti-GBM antibody, and renal biopsy revealed crescentic necrotizing glomerulonephritis with linear immunoglobulin G (IgG) 1 deposition along GBM. Diagnoses: The patient's plasma contained autoantibodies against Goodpasture antigen, which is the NC domain of collagen IVα3, and CD4-positive helper T cells were found surrounding crescent glomeruli with the coexistence CD20-positive B cells. Interventions: Rituximab with steroid and plasma exchange. Outcomes: The levels of autoantibody for Goodpasture antigen were reduced, and the patient was able to temporarily withdraw from hemodialysis. Lessons: B cell depletion with rituximab is effective as an initial therapy for anti-GBM disease.
Funding Information
  • a research donation from Dr. Naohiko Kobayashi, Director of Kobayashi Medical Clinic, in Yasuzuka, Mibu (2018-9)

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