Methyltransferases modulate RNA stability in embryonic stem cells
Authors:
- 31 January 2014
- journal article
- editorial
- Published by Springer Nature in Nature Cell Biology
- Vol. 16 (2) , 129-131
Abstract
Emerging data support that RNA methylation plays important roles in RNA processing and metabolism. The methyltransferases Mettl3 and Mettl14 are shown to catalyse N(6)-methyladenosine (m(6)A) RNA modification in embryonic stem cells (ESCs). This m(6)A modification controls RNA metabolism and functions to destabilize mRNAs encoding developmental regulators to help sustain ESC self-renewal.Keywords
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