A Controlled Clinical Trial of Bupropion for Attention Deficit Hyperactivity Disorder in Adults

Authors:
  • TSThomas J. Spencer
    Thomas J. Spencer
  • JBJoseph Biederman
    Joseph Biederman
  • KGKristine Girard
    Kristine Girard
  • RDRobert Doyle
    Robert Doyle
  • JPJefferson Prince
    Jefferson Prince
  • DPDavid Polisner
    David Polisner
  • RSRamon Solhkhah
    Ramon Solhkhah
  • SCSharyn Comeau
    Sharyn Comeau
  • MMMichael C. Monuteaux
    Michael C. Monuteaux
  • APAsha Parekh
    Asha Parekh
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Abstract
OBJECTIVE: Despite the increasing recognition of attention deficit hyperactivity disorder (ADHD) in adults, there is a paucity of controlled pharmacological trials demonstrating the effectiveness of compounds used in treatment, particularly nonstimulants. The authors report results from a controlled investigation to determine the anti-ADHD efficacy of bupropion in adult patients with DSM-IV ADHD. METHOD: This was a double-blind, placebo-controlled, randomized, parallel, 6-week trial comparing patients receiving sustained-release bupropion (up to 200 mg b.i.d.) (N=21) to patients receiving placebo (N=19). The authors used standardized structured psychiatric instruments for diagnosis of ADHD. To measure improvement, they used separate assessments of ADHD, depression, and anxiety symptoms at baseline and each weekly visit. RESULTS: Of the 40 subjects (55% male) enrolled in the study, 38 completed the study. Bupropion treatment was associated with a significant change in ADHD symptoms at the week-6 endpoint (...

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