Immunological and virological effects of long term IL-2 therapy in HIV-1-infected patients
Authors:
- Christine RouziouxCRChristine Rouzioux
- Isabelle LibermanILIsabelle Liberman
- Marianne BurgardMBMarianne Burgard
- Yacine TaoufikYTYacine Taoufik
- Jean-Paul ViardJVJean-Paul Viard
- Kheira BouchenafaKBKheira Bouchenafa
- Catherine CapitantCCCatherine Capitant
- Jean-François DelfraissyJDJean-François Delfraissy
- 1 September 2001
- journal article
- research article
- Published by Wolters Kluwer Health in AIDS
- Vol. 15 (13) , 1729-1731
Abstract
We report the long-term outcome of 27 HIV-infected patients treated for over 3 years with IL-2 and binucleoside analogues. These patients experienced a sustained increase in CD4 cells and a decrease of proviral DNA with infrequent IL-2 cycles. In three cases, virus could not be isolated from activated peripheral cells. A high frequency of HIV-1-specific memory CD4 T cells was found in the patients studied. IL-2 maintains specific effector cells and reduces the pool of infected cells in patients, albeit treated only with binucleosides.Keywords
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