SCnorm: robust normalization of single-cell RNA-seq data
Open Access
- 17 April 2017
- journal article
- research article
- Published by Springer Nature in Nature Methods
- Vol. 14 (6) , 584-586
Abstract
SCnorm normalizes single-cell RNA-seq data for improved downstream analyses such as differential expression and cell-state discrimination. The normalization of RNA-seq data is essential for accurate downstream inference, but the assumptions upon which most normalization methods are based are not applicable in the single-cell setting. Consequently, applying existing normalization methods to single-cell RNA-seq data introduces artifacts that bias downstream analyses. To address this, we introduce SCnorm for accurate and efficient normalization of single-cell RNA-seq data.Keywords
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