Nitric oxide release from S-nitrosoglutathione (GSNO)

Authors:
  • DNDarren R. Noble
    Darren R. Noble
  • HSHelen R. Swift
    Helen R. Swift
  • DWD. Lyn H. Williams
    D. Lyn H. Williams
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Abstract
In the presence of Cu2+ (10–5 M) very little NO is generated from GSNO at ≡10–3 M at pH 7.4, whereas the reaction is quantitative at ≡10–6 M; this is explicable in terms of the complexation of Cu2+ by the product GSSG.