The anomalous effect of some ACTH‐fragments missing the amino acid sequence 1–10 on the corticosteroidogenesis in purified isolated rat adrenal cells
Authors:
- H.J.M. GoverdeHGH.J.M. Goverde
- A.G.H. SmalsASA.G.H. Smals
- 23 July 1984
- journal article
- Published by Wiley in FEBS Letters
- Vol. 173 (1) , 23-26
Abstract
The corticosteroidogenicity of ACTH‐derived peptides was tested in a purified isolated rat adrenal cell system. The activity was related to the activity of standard ACTH (synthetic hACTH1–39; potency fixed at 100). The peptides ACTH11–19NH2 and ACTH11–24 showed steroidogenicity at pharmacological doses (potencies: 0.00067 and 0.00032, respectively). None of the peptides tested inhibited or potentiated the ACTH‐induced steroidogenesis at low doses (0.5–50 000 pg). The results suggest the presence of a second center within the ACTH molecule capable of inducing steroidogenesis.Keywords
This publication has 16 references indexed in Scilit:
- Structure and function in neuropeptidesProceedings of the Royal Society of London. B. Biological Sciences, 1980
- ACTH-Induced lipolysis in rat adipocytes: Structure-activity relationshipsNaunyn-Schmiedeberg's Archives of Pharmacology, 1978
- Evidence for separate peptide sequences related to the lipolytic and magnesium-accumulating activities of ACTH. Analogy with adrenergic receptorsJournal of Medicinal Chemistry, 1977
- Adrenal cortex adenylate cyclaseNaunyn-Schmiedeberg's Archives of Pharmacology, 1976
- Hormone‐Receptor Interactions. Demonstration of Two Message Sequences (Active Sites) in α‐MelanotropinHelvetica Chimica Acta, 1975
- Synthetische Analoga des Corticotropins. Der Beitrag von Lysin in Position 11 zur biologischen WirkungHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1973
- Die Synthese von menschlichem adrenocorticotropem Hormon (αh‐ACTH) mit revidierter AminosäuresequenzHelvetica Chimica Acta, 1972
- Isolated adrenal cells: ACTH11–24, a competitive antagonist of ACTH1–39 and ACTH1–10FEBS Letters, 1971
- Isolated adrenal cells: Log dose response curves for steroidogenesis induced by ACTH1–24, ACTH1–10, ACTH4–10 and ACTH5–10FEBS Letters, 1971
- Correlation of Adrenocorticotropic Activity of ACTH Analogs with Degree of Binding to an Adrenal Cortical Particulate PreparationProceedings of the National Academy of Sciences, 1970