A brachydin-rich fraction from Fridericia platyphylla induces apoptosis in breast cancer cells via upregulation of AIFM1 and BAX and reduced tumor growth in vivo
Authors:
- Celina Yung-Ai Lin LeeCLCelina Yung-Ai Lin Lee
- Anna Gabriele Prado dos SantosASAnna Gabriele Prado dos Santos
- Andresa Hiromi SakaiASAndresa Hiromi Sakai
- Erica Romão PereiraEPErica Romão Pereira
- Julia Ayumi Ikeda KawasakiJKJulia Ayumi Ikeda Kawasaki
- Samuel dos Santos Soares BunaSBSamuel dos Santos Soares Buna
- Cláudia Quintino da RochaCláudia Quintino da Rocha
- Matheus Reis Santos de MeloMMMatheus Reis Santos de Melo
- Diego Luís RibeiroDiego Luís Ribeiro
- Heloiza Diniz NicolellaHNHeloiza Diniz Nicolella
- Fernanda de Freitas NoronhaFNFernanda de Freitas Noronha
- Arthur Barcelos RibeiroARArthur Barcelos Ribeiro
Open Access
- 23 September 2026
- journal article
- Published by Elsevier in Journal of Ethnopharmacology
- Vol. 374
Abstract
No abstract availableFunding Information
- Fundação Araucária
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Finance Code 001)
- Fundacion Araucaria
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (PPBio/ 441189/2023-7)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (FitoAmaz\u00F4nia/445615/2024-9)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (406707/2025-1)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (303811/2025-0)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (406560/2025-0)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (307379/2023-0)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (404610/2021-8)
This publication has 74 references indexed in Scilit:
- Modulatory Effects of Cirsimarin on Lung Cancer A549 Cells Migration in 2D and 3D Cultures Involves Transcriptional Regulation of MetalloproteinasesJournal of Biochemical and Molecular Toxicology, 2026
- The Emerging Role of Natural Products in Cancer TreatmentArchives of Toxicology, 2024
- Comet Assay for the Detection of Single and Double-Strand DNA Breaks2021
- Cell survival after DNA damage in the comet assayArchives of Toxicology, 2021
- Aglycone flavonoid brachydin A shows selective cytotoxicity and antitumoral activity in human metastatic prostate (DU145) cancer cellsCytotechnology, 2021
- Chemotherapy: a double-edged sword in cancer treatmentCancer Immunology, Immunotherapy, 2021
- Anti-Melanoma Activity of Indomethacin Incorporated into Mesoporous Silica NanoparticlesPharmaceutical Research, 2020
- Cell death: a review of the major forms of apoptosis, necrosis and autophagyCell Biology International, 2019
- An improved syngeneic orthotopic murine model of human breast cancer progressionBreast Cancer Research and Treatment, 2014
- Single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testingEnvironmental and Molecular Mutagenesis, 2000