Supplementary Figures 1-9 from Predisposition Footprints in the Somatic Genome of Wilms Tumors

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Abstract
Contains Supplementary Figures 1-9. Supplementary Figure 1 shows age of diagnosis of children and indel burden and rearrangement burden for tumours from predisposed children versus those with sporadic disease. Supplementary Figure 2 shows genomic evidence for novel predispositions. Supplementary Figure 3 shows global methylation patterns. Supplementary Figure 4 shows differential gene expression. Supplementary Figure 5 shows mutational signatures. Supplementary Figure 6 shows histological subtypes across predispositions and across somatic drivers. Supplementary Figure 7 shows polyclonal versus clonal enrichment of 11p LOH in normal kidneys. Supplementary Figure 8 shows phylogenies in children with multiple neoplasms and either WT1 or TRIM28 predispositions. Supplementary Figure 9 shows phylogenies in children with non WT1/ non TRIM28 predispositions or sporadic disease.