Prokineticin 2 potentiates acid-sensing ion channel activity in rat dorsal root ganglion neurons
Open Access
- 29 May 2012
- journal article
- research article
- Published by Springer Nature in Journal of Neuroinflammation
- Vol. 9 (1) , 108
Abstract
Prokineticin 2 (PK2) is a secreted protein and causes potent hyperalgesia in vivo, and is therefore considered to be a new pronociceptive mediator. However, the molecular targets responsible for the pronociceptive effects of PK2 are still poorly understood. Here, we have found that PK2 potentiates the activity of acid-sensing ion channels in the primary sensory neurons.Keywords
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