For almost 70 years, Clinical Chemistry has been a leading journal that has communicated advances in the clinical laboratory and shaped the identity of laboratory professionals. As a journal of the American Association for Clinical Chemistry (AACC), Clinical Chemistry continues to serve the members of AACC and the larger healthcare community. This current issue is the first published under a new editorial board. The tenure of the former editor-in-chief, Nader Rifai, was marked by success in the publication of landmark original research and the expansion of educational content including innovations such as clinical case studies, podcasts, and journal clubs. A key opportunity for the new editorial board will be to maintain and build upon the achievements of Dr. Rifai and of previous editors.