Lack of Clinical Significance of Early Ischemic Changes on Computed Tomography in Acute Stroke

Authors:
  • SLSteven R. Levine
    Steven R. Levine
  • BTBarbara C. Tilley
    Barbara C. Tilley
  • JGJames C. Grotta
    James C. Grotta
  • MLMei Lu
    Mei Lu
  • MFMichael Frankel
    Michael Frankel
  • JHJr E. Clarke Haley
    Jr E. Clarke Haley
  • TBThomas G. Brott
    Thomas G. Brott
  • JBJoseph P. Broderick
    Joseph P. Broderick
  • SHSteven Horowitz
    Steven Horowitz
  • PLPatrick D. Lyden
    Patrick D. Lyden
  • CLChristopher A. Lewandowski
    Christopher A. Lewandowski

Abstract
In patients with acute ischemic stroke treated with recombinant tissue plasminogen activator (rt-PA) within 3 hours of stroke onset, the National Institute of Neurological Disorders and Stroke (NINDS) rt-PA Stroke Study Group reported a highly statistically significant therapeutic effect at 3 months,1 which was sustained at 1 year.2

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