Facile Synthesis of 1,2,4-Oxadiazoles by the Cycloaddition of N-Hydroxybenzimidoyl Chlorides and Nitriles under Mild Conditions
- 21 August 2026
- journal article
- Published by Georg Thieme Verlag KG in Synthesis
Abstract
We report a mild synthesis of 1,2,4-oxadiazoles via the dipolar cycloaddition of N-hydroxybenzimidoyl chlorides with nitriles under metal-free and catalyst-free conditions. We demonstrate a wide-substrate scope with aryl, heteroaryl, and alkyl substituents on both substrates with yields up to 91%.Keywords
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