Conflicting selection pressures on synonymous codon use in yeast suggest selection on mRNA secondary structures
Open Access
- 1 January 2008
- journal article
- Published by Springer Nature in BMC Ecology and Evolution
- Vol. 8 (1) , 224
Abstract
Eukaryotic mRNAs often contain secondary structures in their untranslated regions that are involved in expression regulation. Whether secondary structures in the protein coding regions are of functional importance remains unclear: laboratory studies suggest stable secondary structures within the protein coding sequence interfere with translation, while several bioinformatic studies indicate stable mRNA structures are more frequent than expected.Keywords
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