Independent association of T cell receptor beta and gamma chains with CD3 in the same cell.
Authors:
- F KoningFKF Koning
- W L MaloyWMW L Maloy
- D CohenDCD Cohen
- J E ColiganJCJ E Coligan
Open Access
- 1 August 1987
- journal article
- research article
- Published by Rockefeller University Press in Journal of Experimental Medicine
- Vol. 166 (2) , 595-600
Abstract
We have demonstrated that the PEER cell line, which expresses a CD3-associated TCR gamma chain on the cell surface, synthesizes TCR beta chain intracellularly. A percentage of this TCR beta chain associates with the CD3 complex intracellularly. These results indicate that TCR beta and gamma chains can be synthesized by one cell line, and that these chains can independently associate with the CD3 complex. However, the results argue against the formation of TCR beta gamma chain complexes in this cell line.Keywords
This publication has 15 references indexed in Scilit:
- Two forms of the T-cell receptor γ protein found on peripheral blood cytotoxic T lymphocytesNature, 1987
- A T-cell receptor γ/CD3 complex found on cloned functional lymphocytesNature, 1987
- Developmentally regulated rearrangement and expression of genes encoding the T cell receptor-T3 complexCell, 1986
- A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytesNature, 1986
- Identification of a putative second T-cell receptorNature, 1986
- Rearrangement and expression of the alpha, beta, and gamma chain T cell receptor genes in human thymic leukemia cells and functional T cells.Journal of Experimental Medicine, 1986
- The Antigen-Specific, Major Histocompatibility Complex-Restricted Receptor on T Cells1986
- Expression of T-cell antigen receptor genes during fetal development in the thymusNature, 1985
- Developmental regulation of T-cell receptor gene expressionNature, 1985
- Cross-linking of human T cell receptor proteins: association between the T cell idiotype β subunit and the T3 glycoprotein heavy subunitCell, 1985