Fluvastatin enhances healing of medication−related osteonecrosis of the jaw (MRONJ) via macrophage polarization in a rat MRONJ−like model
Authors:
- Moa TazakiMTMoa Tazaki
- Koma SandaKSKoma Sanda
- Hiroko WadaHWHiroko Wada
- Bin JiBJBin Ji
- Yohei JinnoYJYohei Jinno
- Yasunori AyukawaYAYasunori Ayukawa
Open Access
- 27 December 2025
- journal article
- Published by Elsevier in Journal of Dental Sciences
Abstract
No abstract availableFunding Information
- Japan Society for the Promotion of Science
This publication has 35 references indexed in Scilit:
- Therapeutic effect of fluvastatin on medication‐related osteonecrosis of the jawJournal of Periodontology, 2021
- Alendronate/dexamethasone combination therapy worsens soft and hard tissue wound healing around implants in rat maxillaeBone, 2021
- Vasculature submucosal changes at early stages of osteonecrosis of the jaw (ONJ)Bone, 2019
- Multipotent mesenchymal stromal cell sheet therapy for bisphosphonate-related osteonecrosis of the jaw in a rat modelActa Biomaterialia, 2016
- Human macrophage polarization in vitro: Maturation and activation methods comparedImmunobiology, 2014
- Topical Simvastatin Accelerates Wound Healing in Diabetes by Enhancing Angiogenesis and LymphangiogenesisThe American Journal of Pathology, 2012
- Simvastatin augments the efficacy of therapeutic angiogenesis induced by bone marrow-derived mesenchymal stem cells in a murine model of hindlimb ischemiaMolecular Biology Reports, 2011
- Bisphosphonate-associated osteonecrosis of the jaw: A key role of inflammation?Bone, 2009
- Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacyOsteoporosis International, 2008
- Simvastatin Promotes Osteoblast Differentiation and Mineralization in MC3T3-E1 CellsBiochemical and Biophysical Research Communications, 2001