Quantitative proteomic and phosphoproteomic profiling of ischemic myocardial stunning in swine
- 30 March 2020
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Heart and Circulatory Physiology
- Vol. 318 (5) , H1256-H1271
Abstract
We first used ion current-based proteomics and phosphoproteomics to reliably identify novel alterations in protein expression and phosphorylation contributing to contractile dysfunction, extracellular matrix (ECM) damage, and programmed cell death in stunned myocardium and developed a comprehensive swine heart-specific proteome database, which provides a valuable resource for future research in porcine models of cardiovascular diseases.Keywords
Funding Information
- HHS | NIH | National Heart, Lung, and Blood Institute (HL-055324, HL-061610, F32HL-114335)
- American Heart Association (17SDG33660200)
- HHS | NIH | National Center for Advancing Translational Sciences (UL1TR001412)
- U.S. Department of Veterans Affairs (1IO1BX002659)
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