Biocatalyzed preparation of the optically enriched stereoisomers of 4-methyl-2-phenyl-tetrahydro-2H-pyran (Doremox®)
Authors:
- Elisabetta BrennaEBElisabetta Brenna
- Claudio FugantiCFClaudio Fuganti
- Sabrina RonzaniSRSabrina Ronzani
- Stefano SerraStefano Serra
- 1 June 2002
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 80 (6) , 714-723
Abstract
The four stereoisomers of the rose oxide analogue Doremox® were prepared in enantiomerically enriched form by enantiospecific bakers' yeast reduction of suitable derivatives and by lipase-mediated kinetic resolution of diol precursors.Key words: yeast, lipase, odorant, reduction, kinetic resolution.Keywords
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