Pallidal stimulation improves pantothenate kinase–associated neurodegeneration
Authors:
- Enza Maria ValenteEVEnza Maria Valente
- Annalisa DiGiorgioADAnnalisa DiGiorgio
- Philippe CoubesPCPhilippe Coubes
- 25 April 2005
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 57 (5) , 738-741
Abstract
Pantothenate kinase–associated neurodegeneration (PKAN) causes a progressive generalized dystonia which remains pharmacologically intractable. We performed bilateral internal globus pallidus stimulation in six patients with genetically confirmed PKAN who obtained a major and long‐lasting improvement of their painful spasms, dystonia, and functional autonomy. This study shows the benefits of pallidal DBS for the dystonia of PKAN patients. Ann Neurol 2005;57:738–741Keywords
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