Fenretinide differentially modulates the levels of long- and very long-chain ceramides by downregulating Cers5 enzyme: evidence from bench to bedside
- 10 July 2017
- journal article
- clinical trial
- Published by Springer Nature in Journal of Molecular Medicine
- Vol. 95 (10) , 1053-1064
Abstract
Cystic fibrosis is the most common genetic disease, in which symptoms may be alleviated but not fully eliminated. Ceramides have long been implicated in thKeywords
Funding Information
- Ministère du Développement Économique, de l'Innovationet de l'Exportation (MDEIE/MESRST)
- Fondo Nacional de Ciencia Tecnología e Innovación (G2005000389)
- Ministère du Développement Économique, de l'Innovationet de l'Exportation (MDEIE/MESRST) (Ministère du Développement Économique, de l'Innovationet de l'Exportation (MDEIE/MESRST))
- Frederick Banting and Charles Best Canada Graduate Scholarships Doctoral Award
- Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada
- Cystic Fibrosis Canada
- Groupe de Recherche Axé sur la Structure des Protéins (GRASP)
- Canadian Institutes of Health Research
- Cystic Fibrosis Foundation
This publication has 46 references indexed in Scilit:
- Ceramide Synthases Expression and Role of Ceramide Synthase-2 in the Lung: Insight from Human Lung Cells and Mouse ModelsPLOS ONE, 2013
- Modulation of Ceramide Synthase Activity via DimerizationJournal of Biological Chemistry, 2012
- PPARγ as a therapeutic target in cystic fibrosisTrends in Molecular Medicine, 2012
- C‐Myc is a Nrf2‐interacting protein that negatively regulates phase II genes through their electrophile responsive elementsIUBMB Life, 2010
- Mammalian ceramide synthasesIUBMB Life, 2010
- Pharmacological correction of a defect in PPAR-γ signaling ameliorates disease severity in Cftr-deficient miceNature Medicine, 2010
- Peroxisome proliferator-activated receptor-γ in cystic fibrosis lung epitheliumAmerican Journal of Physiology-Lung Cellular and Molecular Physiology, 2008
- Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane raftsNature Medicine, 2003
- CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lungNature Medicine, 2002
- Ceramide Enables Fas to Cap and KillJournal of Biological Chemistry, 2001