Alcohol‐Directed Carboamination of Conjugated Enynes

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Abstract
We report a Pd‐catalyzed carboamination of conjugated enynes for the direct synthesis of functionalized allenic amines. The reaction proceeds through a selective 1,4‐coupling of anilines and aryl triflates with enynes, utilizing a free alcohol as a native directing group. The obtained allenes undergo versatile transformations, including cyclization to dihydropyrans, hydroamination, and tandem carboamination sequences. Notably, the use of primary anilines enables a second carboamination to generate multifunctionalized 3‐pyrroline heterocycles through dual C‐N bond formation with two distinct aryl triflates. The transformation represents a novel approach to allene synthesis and heterocycle construction through sequential carboamination events.
Funding Information
  • École Polytechnique Fédérale de Lausanne (180544)
  • École Polytechnique Fédérale de Lausanne (225147)

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