Gene-dosage effects in Down syndrome and trisomic mouse models
Open Access
- 1 January 2004
- journal article
- review article
- Published by Springer Nature in Genome Biology
- Vol. 5 (10) , 244
Abstract
The abnormalities found in human Down syndrome (trisomy 21) have been thought to result from increased expression of genes on chromosome 21 because of their higher gene dosage. Now, several groups have shown this to be generally the case, but some inter-individual variability and other exceptions were found.Keywords
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