Immune Alterations and Viral Reservoir Atlas in SIV-Infected Chinese Rhesus Macaques
Authors:
- Julien A. ClainJCJulien A. Clain
- Morgane PicardMPMorgane Picard
- Henintsoa RabezanaharyHRHenintsoa Rabezanahary
- Sonia AndréSASonia André
- Steven BoutraisSBSteven Boutrais
- Ella Goma MatsetseEMElla Goma Matsetse
- Juliette DewatinesJDJuliette Dewatines
- Quentin DueymesQDQuentin Dueymes
- Elise ThiboutotETElise Thiboutot
- Gina RacineGRGina Racine
- Calaiselvy SoundaramourtyCSCalaiselvy Soundaramourty
- Fabrizio MammanoFMFabrizio Mammano
Open Access
- 6 February 2025
- journal article
- review article
- Published by MDPI AG in Infectious Disease Reports
- Vol. 17 (1) , 12
Abstract
Background/Objectives: Over the last decades, our projects have been dedicated to clarifying immunopathological and virological events associated with Human Immunodeficiency Virus (HIV) infection. Methods: By using non-human primate models of pathogenic and non-pathogenic lentiviral infections, we aimed at identifying the cells and tissues in which the virus persists, despite antiretroviral therapy (ART). Indeed, the eradication of viral reservoirs is a major challenge for HIV cure. Results: We present a series of results performed in rhesus macaques of Chinese origin deciphering the virological and immunological events associated with ART that can be of interest for people living with HIV. Conclusions: This model could be of interest for understanding in whole body the clinical alteration that persist despite ART.Keywords
Funding Information
- ANRS maladies infectieuses émergentes (ANRS-MIE) (HBF-123682, PJT-175182, HBF-126786, MOP-142195, MOP-133476, HIG-133050, HB2-164064)
- Canadian Institutes of Health Research (CIHR) (HBF-123682, PJT-175182, HBF-126786, MOP-142195, MOP-133476, HIG-133050, HB2-164064)
- CANFAR (HBF-123682, PJT-175182, HBF-126786, MOP-142195, MOP-133476, HIG-133050, HB2-164064)
- Laval University (HBF-123682, PJT-175182, HBF-126786, MOP-142195, MOP-133476, HIG-133050, HB2-164064)
- CHU de Québec (Formation Desjardins pour la Recherche et l’Innovation) (HBF-123682, PJT-175182, HBF-126786, MOP-142195, MOP-133476, HIG-133050, HB2-164064)
- Fonds de recherche du Québec—Nature et technologie (FRQNT) (HBF-123682, PJT-175182, HBF-126786, MOP-142195, MOP-133476, HIG-133050, HB2-164064)
- Fonds de Recherche du Québec—Santé (FRQS) (HBF-123682, PJT-175182, HBF-126786, MOP-142195, MOP-133476, HIG-133050, HB2-164064)
- Ensemble Contre le Sida (Sidaction) (HBF-123682, PJT-175182, HBF-126786, MOP-142195, MOP-133476, HIG-133050, HB2-164064)
- Instituts de recherche en santé du Canada (IRSC) (HBF-123682, PJT-175182, HBF-126786, MOP-142195, MOP-133476, HIG-133050, HB2-164064)
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