Ontogeny of Receptor Binding Sites for [3H]Glutamic Acid and [3H]Kainic Acid in the Rat Cerebellum
Authors:
- 1 August 1981
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 37 (2) , 531-533
Abstract
The development of the specific binding sites for l‐[3H]glutamic acid (KD= 370 nM) and for [3H]kainic acid (KD= 39 nM) was studied in the rat cerebellum. Specific binding at both sites remains low during the first week after birth but increases markedly during the second and third weeks after birth, when glutamatergic parallel fiber synaptogenesis occurs. The development of the kainate site lags behind that of the glutamate site, indicating their autonomy.Keywords
This publication has 16 references indexed in Scilit:
- The antagonism of amino acid-induced excitation of spinal neurones in the catBrain Research, 1979
- Toxic effects of kainic acid on mouse cerebellum in tissue cultureBrain Research, 1979
- HIGH AFFINITY l‐[3H]GLUTAMATE BINDING TO POSTSYNAPTIC RECEPTOR SITES ON RAT CEREBELLAR MEMBRANESJournal of Neurochemistry, 1978
- Influence of cortico-striatal afferents on striatal kainic acid neurotoxicityNeuroscience Letters, 1978
- Kainate-induced degeneration of neostriatal neurons: dependency upon corticostriatal tractBrain Research, 1978
- BINDING OF [3H]KAINIC ACID, AN ANALOGUE OF l‐GLUTAMATE, TO BRAIN MEMBRANESJournal of Neurochemistry, 1976
- Potentiation of glutamate-induced depolarization by kainic acid in the crayfish opener muscleNeuropharmacology, 1974
- Postnatal development of the cerebellar cortex in the rat. II. Phases in the maturation of Purkinje cells and of the molecular layerJournal of Comparative Neurology, 1972
- The ontogenetic development of synaptic junctions, synaptic activation and responsiveness to neurotransmitter substances in rat cerebellar purkinje cellsBrain Research, 1971
- Actions of several anthelmintics and insecticides on rat cortical neuronesBrain Research, 1970