Human ancestry correlates with language and reveals that race is not an objective genomic classifier
Open Access
- 8 May 2017
- journal article
- research article
- Published by Springer Nature in Scientific Reports
- Vol. 7 (1) , 1-10
Abstract
Genetic and archaeological studies have established a sub-Saharan African origin for anatomically modern humans with subsequent migrations out of Africa. Using the largest multi-locus data set known to date, we investigated genetic differentiation of early modern humans, human admixture and migration events, and relationships among ancestries and language groups. We compiled publicly available genome-wide genotype data on 5,966 individuals from 282 global samples, representing 30 primary language families. The best evidence supports 21 ancestries that delineate genetic structure of present-day human populations. Independent of self-identified ethno-linguistic labels, the vast majority (97.3%) of individuals have mixed ancestry, with evidence of multiple ancestries in 96.8% of samples and on all continents. The data indicate that continents, ethno-linguistic groups, races, ethnicities, and individuals all show substantial ancestral heterogeneity. We estimated correlation coefficients ranging from 0.522 to 0.962 between ancestries and language families or branches. Ancestry data support the grouping of Kwadi-Khoe, Kx’a, and Tuu languages, support the exclusion of Omotic languages from the Afroasiatic language family, and do not support the proposed Dené-Yeniseian language family as a genetically valid grouping. Ancestry data yield insight into a deeper past than linguistic data can, while linguistic data provide clarity to ancestry data.Keywords
This publication has 61 references indexed in Scilit:
- Autosomal and uniparental portraits of the native populations of Sakha (Yakutia): implications for the peopling of Northeast EurasiaBMC Ecology and Evolution, 2013
- Ethiopian Genetic Diversity Reveals Linguistic Stratification and Complex Influences on the Ethiopian Gene PoolThe American Journal of Human Genetics, 2012
- Shared and Unique Components of Human Population Structure and Genome-Wide Signals of Positive Selection in South AsiaThe American Journal of Human Genetics, 2011
- Inference of human population history from individual whole-genome sequencesNature, 2011
- A Revised Root for the Human Y Chromosomal Phylogenetic Tree: The Origin of Patrilineal Diversity in AfricaThe American Journal of Human Genetics, 2011
- Integrating common and rare genetic variation in diverse human populationsNature, 2010
- Population Genetic Structure of the People of QatarThe American Journal of Human Genetics, 2010
- The genome-wide structure of the Jewish peopleNature, 2010
- Ancient human genome sequence of an extinct Palaeo-EskimoNature, 2010
- Principal components analysis corrects for stratification in genome-wide association studiesNature Genetics, 2006