Relationship between Vitamin D Status and Antibody Response to COVID-19 mRNA Vaccination in Healthy Adults

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Abstract
The immune response to vaccination with SARS-CoV-2 vaccines varies greatly from person to person. In addition to age, there is evidence that certain micronutrients influence the immune system, particularly vitamin D. Here, we analysed SARS-CoV-2 IgG and neutralisation potency along with 25-hydroxy-cholecalciferol [25(OH)D] concentrations in a cohort of healthy German adults from the time of vaccination over 24 weeks. Contrary to our expectations, no significant differences were found in the dynamic increase or decrease of SARS-CoV-2 IgG as a function of the 25(OH)D status. Furthermore, the response to the first or second vaccination, the maximum SARS-CoV-2 IgG concentrations achieved, and the decline in SARS-CoV-2 IgG concentrations over time were not related to 25(OH)D status. We conclude that the vaccination response, measured as SARS-CoV-2 IgG concentration, does not depend on 25(OH)D status in healthy adults with moderate vitamin D status.
Funding Information
  • Deutsche Forschungsgemeinschaft (Research Unit FOR-2558 “TraceAge” (Scho 849/6-2), CRC/TR 296 “Local control of TH action” (LocoTact, P17))
  • German Federal Ministry for Economic Affairs and Energy (BMWi) (ZIM program, project #KK5051601BM0)
  • Berlin Institute of Health at Charité - Universitätsmedizin Berlin (to the doctoral thesis of KD)

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