The Continuous Assessment of Cerebrovascular Reactivity: A Validation of the Method in Healthy Volunteers
Authors:
- Stefan K. PiechnikSPStefan K. Piechnik
- Xin YangXYXin Yang
- Marek CzosnykaMCMarek Czosnyka
- Piotr SmielewskiPSPiotr Smielewski
- Sarah H. FletcherSFSarah H. Fletcher
- Andrew L. JonesAJAndrew L. Jones
- John D. PickardJPJohn D. Pickard
- 1 October 1999
- journal article
- Published by Wolters Kluwer Health in Anesthesia & Analgesia
- Vol. 89 (4) , 944
Abstract
Middle cerebral arteries, PETCO2, and ABP were recorded during normocapnia, hypercapnia, and hypocapnia. The moving correlation coefficients between ABP and mean FV (FVm) or systolic FV (FVs) during spontaneous fluctuations in ABP were calculated for 3-min epochs and averaged for each investigation, thus yielding the mean index (Mx) and systolic index (Sx). As a reference method, Aaslid’s cuff tests were performed to obtain the rate of regulation (RoR). RoR, Mx, and Sx significantly depended on PETCO2 (analysis of variance, P< 0.00001). At high PETCO2, cerebrovascular reactivity was disturbed as reflected in RoR values of 0.4 in 86% of volunteers) and Sx (>0.2 in 79% of volunteers). Overall, there was a reasonably good correlation of both Mx and Sx with RoR (R2 = 0.65 and 0.58, respectively). Implications Indices derived from the correlation between spontaneous fluctuations of blood flow velocity wave form and arterial blood pressure may be used for the noninvasive continuous monitoring of cerebrovascular reactivity....Keywords
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