Chromosomal translocations among the healthy human population: implications in oncogenesis
- 5 September 2012
- journal article
- review article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 70 (8) , 1381-1392
Abstract
Chromosomal translocations are characteristic features of many cancers, especially lymphoma and leukemia. However, recent reports suggest that many chromosomal translocations can be found in healthy individuals, although the significance of this observation is still not clear. In this review, we summarize recent studies on chromosomal translocations in healthy individuals carried out in different geographical areas of the world and discuss the relevance of the observation with respect to oncogenesis.Keywords
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