Advances in Genetics and Epigenetics of Developmental Coordination Disorder in Children

Authors:
Open Access
Publisher website
Google Scholar
Abstract
Developmental coordination disorder (DCD) is a developmental disorder characterized by impaired motor coordination, often co-occurring with attention deficit disorder, autism spectrum disorders, and other psychological and behavioural conditions. The aetiology of DCD is believed to involve brain changes and environmental factors, with genetics also playing a role in its pathogenesis. Recent research has identified several candidate genes and genetic factors associated with motor impairment, including deletions, copy number variations, single nucleotide polymorphisms, and epigenetic modifications. This review provides an overview of the current knowledge in genetic research on DCD, highlighting the importance of continued research into the underlying genetic mechanisms. While evidence suggests a genetic contribution to DCD, the evidence is still in its early stages, and much of the current evidence is based on studies of co-occurring conditions. Further research to better understand the genetic basis of DCD could have important implications for diagnosis, treatment, and our understanding of the condition’s aetiology.
Funding Information
  • National Natural Science Foundation of China (81673179, 21DZ2202000, 19140903100, 2020YJZX0213, PW2020D-11, PWYgts2021-02)
  • Science and Technology Commission of Shanghai Municipality (81673179, 21DZ2202000, 19140903100, 2020YJZX0213, PW2020D-11, PWYgts2021-02)
  • Shanghai Municipal Health Commission (81673179, 21DZ2202000, 19140903100, 2020YJZX0213, PW2020D-11, PWYgts2021-02)
  • Pudong Municipal Health Commission (81673179, 21DZ2202000, 19140903100, 2020YJZX0213, PW2020D-11, PWYgts2021-02)
  • Pudong Health Commission (81673179, 21DZ2202000, 19140903100, 2020YJZX0213, PW2020D-11, PWYgts2021-02)

This publication has 116 references indexed in Scilit: