A Phthalocyanine Derivate Mouthwash to Gargling/Rinsing as an Option to Reduce Clinical Symptoms of COVID-19: Case Series
Authors:
- Bernardo da Fonseca OrcinaBOBernardo da Fonseca Orcina
- Fabiano Vieira VilhenaFVFabiano Vieira Vilhena
- Rodrigo Cardoso de OliveiraRORodrigo Cardoso de Oliveira
- Lucas Marques da Costa AlvesLALucas Marques da Costa Alves
- Koiti ArakiKAKoiti Araki
- Sergio Hiroshi TomaSTSergio Hiroshi Toma
- Mariana Schutzer Ragghianti ZangrandoMZMariana Schutzer Ragghianti Zangrando
- Paulo Sergio da Silva SantosPSPaulo Sergio da Silva Santos
Open Access
- 1 February 2021
- journal article
- research article
- Published by Taylor & Francis in Clinical, Cosmetic and Investigational Dentistry
- Vol. ume 13, 47-50
Abstract
Aim: This case series demonstrated that phthalocyanine derivate mouthwash is a promising alternative for reducing the viral load of SARS-CoV-2 and for clinical improvement of infected patients who presented mild and moderate symptoms. Purpose: The aim of this study was to report a case series of patients diagnosed with COVID-19 that used the phthalocyanine derivate mouthwash to reduce clinical symptoms. Patients and Methods: Eight patients used 5mL of phthalocyanine derivate mouthwash gargling/rinsing for one minute, five times daily, over a fourteen day period. Two measurement scales were applied for each patient in different periods to verify sore throat – VAS – Visual Analogue Scale for Pain and the clinical conditions – PS – Performance Status. Results: All patients presented a significant reduction in clinical symptoms with the use of the mouthwash for gargling/rinsing after few days of use, without hospitalization. Conclusion: The phthalocyanine derivate mouthwash protocol appears as a potential alternative for clinical improvement of COVID-19 infected patients. Daily use of this mouthwash rapidly reduced clinical symptoms such as sore throats, cough and mouth ulcers. Large, high-quality randomized controlled trials with larger sample size are necessary to confirm the effectiveness of this mouthwash protocol against COVID-19.Keywords
This publication has 9 references indexed in Scilit:
- Preprocedural Use of Povidone-Iodine Mouthwash during Dental Procedures in the COVID-19 PandemicEuropean Journal of Dentistry, 2020
- Virucidal Efficacy of Different Oral Rinses Against Severe Acute Respiratory Syndrome Coronavirus 2The Journal of Infectious Diseases, 2020
- Novel COVID-19: A Comprehensive Review of Transmission, Manifestation, and PathogenesisCureus, 2020
- Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2Science, 2020
- Human Saliva: Non-Invasive Fluid for Detecting Novel Coronavirus (2019-nCoV)International Journal of Environmental Research and Public Health, 2020
- Consistent Detection of 2019 Novel Coronavirus in SalivaClinical Infectious Diseases, 2020
- Clinical Significance of a High SARS-CoV-2 Viral Load in the SalivaJournal of Korean Medical Science, 2020
- Therapeutic efficacy of chlorhexidine‐based mouthwashes and its adverse events: Performance‐related evaluation of mouthwashes added with Anti‐Discoloration System and cetylpyridinium chlorideInternational Journal of Dental Hygiene, 2018
- The minimum clinically significant difference in visual analogue scale pain score does not differ with severity of painEmergency Medicine Journal, 2001