Ultrasmall Fe-doped carbon dots nanozymes for photoenhanced antibacterial therapy and wound healing

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Abstract
Pathogenic bacteria pose a devastating threat to public health. However, because of the growing bacterial antibiotic resistance, there is an urgent need to develop alternative antibacterial strategies to the established antibiotics. Herein, iron-doped carbon dots (Fe-CDs, ∼3 nm) nanozymes with excellent photothermal conversion and photoenhanced enzyme-like properties are developed through a facile one-pot pyrolysis approach for synergistic efficient antibacterial therapy and wound healing. In particular, Fe doping endows CDs with photoenhanced peroxidase (POD)-like activity, which lead to the generation of heat and reactive oxygen species (ROS) for Gram-positive and Gram-negative bacteria killing. This study demonstrates Fe-CDs have significant wound healing efficiency of Fe-CDs by preventing infection, promoting fibroblast proliferation, angiogenesis, and collagen deposition. Furthermore, the ultrasmall size of Fe-CDs possesses good biocompatibility favoring clinical translation. We believe that the nanozyme-mediated therapeutic platform presented here is expected to show promising applications in antibacterial.
Funding Information
  • Fundamental Research Funds for the Central Universities (XK1802-8, buctrc201915)
  • Fundamental Research Funds for the Central Universities
  • National Natural Science Foundation of China (21822802, 22061130205, 51772018)
  • National Key Research and Development Program of China (2016YFA0201500, 2018YFC1200100)

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