Separation of Beta Adrenoceptor Antagonist Enantiomers by High Resolution Capillary Gas Chromatography

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Abstract
The diastereoisomers of beta adrenoceptor antagonists have been separated by gas-liquid chromatography. Enantiomers were reacted with N-trifluoroacetyl-l-prolyl-chloride (TPC), N-heptafluorobutyryl-l-prolyl-chloride (HPC) and N,O-bis-(trimethylsilyl)trifluoroacetamide and separated on packed and glass open-tubular columns. Application of the procedure for quantitative determination of the enantiomers is discussed.