Steady-state protriptyline levels in an outpatient population

Authors:
  • JBJ T Biggs
    J T Biggs
  • WHW H Holland
    W H Holland
  • WSW R Sherman
    W R Sherman
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Abstract
The authors measured steady-state protriptylive levels in 12 outpatients undergoing treatment for depression. The steady-state level of protriptyline was surprisingly high compared with levels obtained when other tricyclic antidepressants were prescribed. This finding probably accounts for the effectiveness of protriptyline at low doses and its frequent side effects.