Elevation of the vitreous body concentrations of oxidative stress-responsive apoptosis-inducing protein (ORAIP) in proliferative diabetic retinopathy

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Abstract
Oxidative stress has been implicated in the pathogenesis of various disorders, including diabetic retinopathy (DR). Oxidative stress-responsive apoptosis-inducing protein (ORAIP; a tyrosine-sulfated secreted form of eukaryotic translation initiation factor 5A [eIF5A]) is a recently discovered pro-apoptotic ligand that is secreted from cells in response to oxidative stress and induces apoptosis in an autocrine fashion. This study aimed to determine if ORAIP plays a role in DR.
Funding Information
  • Takeda Research Support (-)
  • Novartis Pharma Research Grants (-)
  • Alcon Pharmaceuticals (-)
  • Senju Pharmaceutical Co. Ltd (-)
  • Bayer Pharmaceuticals Co. Ltd (-)

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