Oxygen uptake kinetics and chronotropic responses to exercise are impaired in survivors of severe COVID-19

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Abstract
Our findings provide novel data regarding the impact of COVID-19 on submaximal and maximal cardiopulmonary responses to exercise. We showed that V̇o2 kinetics is significantly impaired at both the onset (on-transient) and the recovery phase (off-transient) of exercise in these patients. Furthermore, our results suggest that survivors of severe COVID-19 may have a higher metabolic demand at a walking pace. These findings may partly explain the exertional intolerance frequently observed following COVID-19.
Funding Information
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (88887.624726/2021-00)
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (2020/07540-4)
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (2017-13552-2)
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (2019-18039-7)
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (2020/15678-6)
  • MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico (308307/2021-6)

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