Core‐Cone Structured Monodispersed Mesoporous Silica Nanoparticles with Ultra‐large Cavity for Protein Delivery
Abstract
A new type of monodispersed mesoporous silica nanoparticles with a core–cone structure (MSN‐CC) has been synthesized. The large cone‐shaped pores are formed by silica lamellae closely packed encircling a spherical core, showing a structure similar to the flower dahlia. MSN‐CC has a large pore size of 45 nm and a high pore volume of 2.59 cm3 g−1. MSN‐CC demonstrates a high loading capacity of large proteins and successfully delivers active β‐galactosidase into cells, showing their potential as efficient nanocarriers for the cellular delivery of proteins with large molecular weights.Keywords
Funding Information
- Australian Research Council
- Queensland Government
- Australian National Fabrication Facility
- Australian Microscopy and Microanalysis Research Facility at the Centre for Microscopy and Microanalysis
- University of Queensland
This publication has 35 references indexed in Scilit:
- Altered characteristics of silica nanoparticles in bovine and human serum: the importance of nanomaterial characterization prior to its toxicological evaluationParticle and Fibre Toxicology, 2013
- Efficient Cellular Delivery of β-Galactosidase Mediated by NrTPs, a New Family of Cell-Penetrating PeptidesBioconjugate Chemistry, 2011
- Local Release of Highly Loaded Antibodies from Functionalized Nanoporous Support for Cancer ImmunotherapyJournal of the American Chemical Society, 2011
- Delivery of Therapeutic ProteinsJournal of Pharmaceutical Sciences, 2010
- Nanoparticle-Mediated Cytoplasmic Delivery of Proteins To Target Cellular MachineryACS Nano, 2010
- Intracellular Delivery of a Membrane-Impermeable Enzyme in Active Form Using Functionalized Gold NanoparticlesJournal of the American Chemical Society, 2010
- Colloidal Suspensions of Nanometer‐Sized Mesoporous SilicaAdvanced Functional Materials, 2007
- Viscoelastic micellar solutions: microscopy and rheologyThe Journal of Physical Chemistry, 1992
- Shape transformations of vesicles: Phase diagram for spontaneous- curvature and bilayer-coupling modelsPhysical Review A, 1991
- The Determination of Pore Volume and Area Distributions in Porous Substances. I. Computations from Nitrogen IsothermsJournal of the American Chemical Society, 1951