New Combination Chemotherapy Programme for Bladder Cancer

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Abstract
Summary— Forty patients with either metastatic, post‐radiotherapy recurrent, or poor prognosis locally advanced transitional cell carcinoma of the bladder were treated in a new combination chemotherapy programme with methotrexate, vinblastine, mitozantrone and JM8 (carboplatin); 33 patients were assessable for response. There were 9 complete responses (27%), 12 partial responses (36%) and 7 disease stabilisations (21%); 5 patients (15%) had progressive disease. The median duration of complete response has not been reached and is in excess of 9 months (range 4– > 18 months). This regimen was without significant toxicity and this is in contrast with M‐VAC, which is thought to be currently the most effective treatment for urothelial cancer.